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Table 3 Percentage of cpAC and normal lung biospecimens with TKR phosphorylation

From: Canine pulmonary adenocarcinoma tyrosine kinase receptor expression and phosphorylation

TKR

cpAC n(%)

Normal lung n(%)

EGFR

11 (92)

10 (83)

HER2

12 (100)

11 (92)

HER3

12 (100)

12 (100)

FGFR1

10 (83)

9 (75)

FGFR3

10 (83)

10 (83)

FGFR4

10 (83)

9 (75)

InsR

11 (92)

12 (100)

IGF-IR

12 (100)

12 (100)

TrkA/NTRK1

12 (100)

11 (92)

TrkB/NTRK2

12 (100)

11 (92)

Met/HGFR

10 (83)

10 (83)

Ron/MST1R

11 (92)

10 (83)

Ret

10 (83)

12 (100)

ALK

11 (92)

11 (92)

PDGFR

11 (92)

10 (83)

c-KIT/SCFR

6 (50)

11 (92)

FLT3/Flk2

7 (58)

11 (92)

M-CSFR

9 (75)

11 (83)

EphA1

11 (92)

12 (100)

EphA2

11 (92)

11 (92)

EphA3

11 (92)

11 (92)

EphB1

11 (92)

10 (83)

EphB3

12 (100)

10 (83)

EphB4

11 (92)

11 (92)

Tyro-3/Dtk

11 (92)

10 (83)

Axl

7 (58)

12 (100)

Tie/TEK

12 (100)

12 (100)

VEGFR2/KDR

6 (50)

11 (92)

  1. Phosphorylation of biospecimen protein lysate was determined by the presence of fluorescence that was quantified after normalization to the array spotted positive and negative controls for each sample. Each receptor was assayed in duplicates and the mean fluorescence for that receptor was recorded. n, represents the number of positive samples and (%) represents the percentage out of 12 total samples.