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Figure 2 | BMC Veterinary Research

Figure 2

From: Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines

Figure 2

KPT-335 induces apoptosis of canine melanoma cells. Canine melanoma cell lines were treated with DMSO, 0.1 μM KPT-335 or 1 μM KPT-335 for 96 hours. Cells were collected and stained with Annexin V FITC/propidium iodide and analyzed by flow cytometry to quantitate early and late apoptosis. Cells treated with KPT-335 at 0.1 μM and 1 μM demonstrated a substantial increase in early and late apoptosis compared to vehicle treated cells (p < 0.05; with the exception of the Mel 69 in which only the 1 μM late apoptosis group showed statistical significance).

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BMC Veterinary Research

ISSN: 1746-6148

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