MIP-3β/CCL19 is associated with the intrathecal invasion of mononuclear cells in neuroinflammatory and non-neuroinflammatory CNS diseases in dogs

Table 1 CSF and serum characteristics in patients with IE, neuroinflammatory disease, IVDD and clinically healthy patients

	SRMA untreated	SRMA treated	MUO untreated	MUO treated	IVDD 2/3	IVDD 4/5	Healthy	IE (control)^*
No. patients	25(5/4/16)	26	16	11	25	11	6	21
CSF cellcount/3microL	528 (200–3800)^a	1 (0.25-2)	196 (25.8-73 1.8)^b	2 (1–3)	1(1–3)	3 (2.5-4)		1 (0–1)
CSF protein mg/dl	28 (20–55)^c	12 (11–14)	40 (25.3-97.3)	16 (14–20)	19(15–22)	14(10.5-16)		12 (10–14)
CSF Ig A	1.6 (0.4-2.7)	0.2 (0.09-0.45)
Serum Ig A	184 (106–282)	75.4 (47.9-98.7)
Blood leucocvtes	20.7 (18–27)	10.9(9.8-13.9)	10.6(9.7-13.1)	10 (9.7-12)	8(7.5-11)	13.2(8.3-15.7)	10(9–12)	10 (9–12)
xl000/microL
CSF CCL19 pg/ml	1690 (671.5-3200)^{* 'ac}	80.5(68–111.5)^'	373.5 (174.5-776.8)^{* ^ b}	91.8 (76.695)^{^}	108.2 (82–162)^{* d}	149.2 (97.6-207)^*	51.2 (40.1-54.2)^*	66(56–87.1)
Serum CCL19 pg/ml	129.3 (73–198)	84.5(35.5-131.9)	160.6 (79.7-467.9)	51.8 (32.4-190)	146.4 (73–191)^d	97.6 (47–129.3)	108.9 (90.4-192)	88.3 (55.8-127)

SRMA = steroid-responsive meningitis-arteritis; MUO = meningoencephalomyelitis of unknown origin; IVDD = intervertebral disc disease; IE = idiopathic epilepsy; Ig = immunoglobulin; No = number; CSF = cerebrospinal fluid; pg = picogram; microL = microliter; ml = milliliter; mg = milligram; SRMA untreated: n = 25 total; n = 5 one time pre-treated; n = 4 relapse; n = 16 untreated.
^*Statistically significant differences, CSF CCL19 comparison SRMA, MUO, IVDD, healthy with IE (control).
^'Statistically significant differences, CSF CCL19 comparison SRMA untreated with SRMA treated.
^{^}Statistically significant differences, CSF CCL19 comparison MUO untreated with MUO treated.
^aStatistically significant differences, correlation SRMA CSF cell count with CSF CCL19.
^bStatistically significant differences, correlation MUO CSF cell count with CSF CCL19.
^cStatistically significant differences, correlation SRMA CSF protein with CSF CCL19.
^dStatistically significant differences, correlation IVDD CSF CCL19 with Serum CCL19.
Data are provided as medians (25th- 75th percentiles).

ISSN: 1746-6148