Identification of serum biomarkers in dogs naturally infected with Babesia canis canis using a proteomic approach

Kuleš, Josipa; Mrljak, Vladimir; Rafaj, Renata Barić; Selanec, Jelena; Burchmore, Richard; Eckersall, Peter D

doi:10.1186/1746-6148-10-111

Table 2 Protein identification of differentially expressed proteins

From: Identification of serum biomarkers in dogs naturally infected with Babesia canis canis using a proteomic approach

Protein name	Accession number^a	Number of unique peptides^b	Sequence coverage (%)^b	Mascot score^b	Biological function	Spot no.^c
Alpha-1-acid glycoprotein	gi\|345777714	25	53	628	Acute phase response	596, 579
Apolipoprotein A-I	gi\|73955106	70	72	1834	Cholesterol, lipid and steroid metabolism	869, 432
Apolipoprotein A-I	gi\|73955106	70	72	1834	Lipid transport	869, 432
Antithrombin-III	gi\|359320010	5	19	161	Blood coagulation	432
Vitamin D-binding protein	gi\|73975215	24	57	543	Vitamin D metabolic process	432
Apolipoprotein A-IV	gi\|345799905	66	72	1401	Removal of superoxide radicals	590
Apolipoprotein A-IV	gi\|345799905	66	72	1401	Lipid metabolism	590
Complement C3	gi\|359322249	16	15	356	Complement activation (classical and alternative pathway)	590
Complement C3	gi\|359322249	16	15	356	Inflammatory response	590
Serotransferrin	gi\|73990142	25	40	672	Cellular iron ion homeostasis	327
Serotransferrin	gi\|73990142	25	40	672	Iron ion transport	327
Hemopexin	gi\|73988725	12	44	273	Cellular iron ion homeostasis	327
Alpha-2-HS-glycoprotein	gi\|359323766	7	40	273	Acute phase response	596, 432
Haptoglobin	gi\|123511	5	41	159	Cellular iron ion homeostasis	579
Haptoglobin	gi\|123511	5	41	159	Acute phase response	579
Alpha-2-antiplasmin	gi\|345805038	3	13	101	Acute phase response	327
Alpha-2-antiplasmin	gi\|345805038	3	13	101	Fibrinolysis	327
Clusterin	gi\|50979240	31	25	864	Apoptosis	596, 579
Clusterin	gi\|50979240	31	25	864	Complement pathway	596, 579
Leucine-rich-α2-glycoprotein	gi\|73987375	24	50	625	Acute phase response	432
Zinc-alpha-2-glycoprotein	gi\|73958037	15	46	310	Immune response	579
Immunoglobulin gamma heavy chain B	gi\|17066526	12	27	206	Immune response	432
Immunoglobulin gamma heavy chain B	gi\|17066526	12	27	206	Complement activation	432
Immunoglobulin gamma heavy chain C	gi\|17066528	10	20	222	Immune response	432
IgA heavy chain constant region	gi\|598107	7	22	124	Immune response	327

^aAccesion number from NCBI Genbank database for Canis lupus familiaris.
^bData are representatives of four separate experimental group.
^cNumber refer to protein spots indicated in Figure 1.

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ISSN: 1746-6148

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